Let’s find a pancreatic cancer trial for you
Let’s find a pancreatic cancer trial for you
North is the fastest way to discover and match with one of the 423 pancreatic cancer trials open in the U.S.
North is the fastest way to discover and match with one of the 423 pancreatic cancer trials open in the U.S.
How North Works
1
5-10 minute health
history intake
5-10 minute health
history intake
2
We’ll send you personalized match results in 1-2 days
We’ll send you personalized match results in 1-2 days
3
We'll connect you with clinical trial coordinators
We'll connect you with clinical trial coordinators
1
5-10 minute health
history intake
2
We’ll send you personalized
match results in 1-2 days
3
We'll connect you with
clinical trial coordinators
Take the next step
Explore trials near you
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Pancreatic cancer trials now enrolling in the U.S.
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Stage 4 pancreatic trials enrolling in the U.S.
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Stage 3 pancreatic trials enrolling in the U.S.
North's expert research advisors
Dr. Mike Gibson
Dr. Mike Gibson
MD, PhD, Division of Hematology and
Oncology, Vanderbilt-Ingram Cancer Center
MD, PhD, Division of Hematology and Oncology, Vanderbilt-Ingram
Cancer Center
Dr. Carol Tweed
Dr. Carol Tweed
Board Certified MD, Hematology and Medical Oncology, Annapolis, Maryland
Board Certified MD, Hematology and
Medical Oncology, Annapolis, Maryland
Holly Hoefer
Holly Hoefer
VP Patient Engagement, Helios
Clinical Research
Dr. Mike Gibson
MD, PhD, Division of Hematology and Oncology, Vanderbilt-Ingram Cancer Center
Dr. Carol Tweed
Board Certified MD, Hematology and Medical Oncology, Annapolis, Maryland
Holly Hoefer
VP Patient Engagement,
Helios Clinical
ResearchDr. Mike Gibson
MD, PhD, Division of Hematology and Oncology, Vanderbilt-Ingram Cancer Center
Dr. Carol Tweed
Board Certified MD, Hematology and Medical Oncology, Annapolis, Maryland
Holly Hoefer
VP Patient Engagement,
Helios Clinical
ResearchDr. Mike Gibson
MD, PhD, Division of Hematology and Oncology, Vanderbilt-Ingram Cancer Center
Dr. Carol Tweed
Board Certified MD, Hematology and Medical Oncology, Annapolis, Maryland
Holly Hoefer
VP Patient Engagement,
Helios Clinical
ResearchDr. Mike Gibson
MD, PhD, Division of Hematology and Oncology, Vanderbilt-Ingram Cancer Center
Dr. Carol Tweed
Board Certified MD, Hematology and Medical Oncology, Annapolis, Maryland
Holly Hoefer
VP Patient Engagement,
Helios Clinical
Research
Questions about pancreatic cancer clinical trials?
Have pancreatic cancer survival rates improved?
Yes, pancreatic cancer survival rates have improved modestly, but they remain low overall.
Five-year survival has increased over the past decade due to better chemotherapy combinations, improved surgery and supportive care, and more biomarker-matched treatments, especially for small subsets of patients. However, most cases are still diagnosed late, which limits larger gains.
Sources:
American Cancer Society – Pancreatic cancer survival statistics
National Cancer Institute (NCI) – SEER pancreatic cancer trends
Journal of Clinical Oncology / ASCO reviews on pancreatic cancer outcomes
Have pancreatic cancer survival rates improved?
Yes, pancreatic cancer survival rates have improved modestly, but they remain low overall.
Five-year survival has increased over the past decade due to better chemotherapy combinations, improved surgery and supportive care, and more biomarker-matched treatments, especially for small subsets of patients. However, most cases are still diagnosed late, which limits larger gains.
Sources:
American Cancer Society – Pancreatic cancer survival statistics
National Cancer Institute (NCI) – SEER pancreatic cancer trends
Journal of Clinical Oncology / ASCO reviews on pancreatic cancer outcomes
Have pancreatic cancer survival rates improved?
Yes, pancreatic cancer survival rates have improved modestly, but they remain low overall.
Five-year survival has increased over the past decade due to better chemotherapy combinations, improved surgery and supportive care, and more biomarker-matched treatments, especially for small subsets of patients. However, most cases are still diagnosed late, which limits larger gains.
Sources:
American Cancer Society – Pancreatic cancer survival statistics
National Cancer Institute (NCI) – SEER pancreatic cancer trends
Journal of Clinical Oncology / ASCO reviews on pancreatic cancer outcomes
What are some of the best clinical trial options for stage 4 pancreatic cancer?
Best is highly subjective, so we encourage you to fill out North's health history intake and we'll send you a personalized list of potential trial matches. In the meantime, here are some examples of the types of trials you may see for stage 4 pancreatic cancer:
KRAS-targeted therapies (especially newer RAS/KRAS inhibitors, often after chemo)
Biomarker-matched trials (e.g., BRCA/PALB2 DNA-repair → PARP maintenance/combos)
New immunotherapy combinations (trying to make “cold” pancreatic tumors respond)
Novel antibody/targeted approaches for select markers (e.g., CLDN18.2 when present)
Sources:
Clinicaltrials.gov
What are some of the best clinical trial options for stage 4 pancreatic cancer?
Best is highly subjective, so we encourage you to fill out North's health history intake and we'll send you a personalized list of potential trial matches. In the meantime, here are some examples of the types of trials you may see for stage 4 pancreatic cancer:
KRAS-targeted therapies (especially newer RAS/KRAS inhibitors, often after chemo)
Biomarker-matched trials (e.g., BRCA/PALB2 DNA-repair → PARP maintenance/combos)
New immunotherapy combinations (trying to make “cold” pancreatic tumors respond)
Novel antibody/targeted approaches for select markers (e.g., CLDN18.2 when present)
Sources:
Clinicaltrials.gov
What are some of the best clinical trial options for stage 4 pancreatic cancer?
Best is highly subjective, so we encourage you to fill out North's health history intake and we'll send you a personalized list of potential trial matches. In the meantime, here are some examples of the types of trials you may see for stage 4 pancreatic cancer:
KRAS-targeted therapies (especially newer RAS/KRAS inhibitors, often after chemo)
Biomarker-matched trials (e.g., BRCA/PALB2 DNA-repair → PARP maintenance/combos)
New immunotherapy combinations (trying to make “cold” pancreatic tumors respond)
Novel antibody/targeted approaches for select markers (e.g., CLDN18.2 when present)
Sources:
Clinicaltrials.gov
What are the last stages of pancreatic cancer?
Stage 3 and 4 are considered late stage pancreatic cancer.
Stage 3 (locally advanced)
Cancer has spread to major nearby blood vessels but not to distant organs
Symptoms often include persistent abdominal/back pain, weight loss, fatigue, jaundice, and digestive problems
Treatment may still aim to control the cancer and prolong survival (chemo ± radiation), alongside symptom management
Stage 4 (metastatic)
Cancer has spread to distant organs (most often liver, lungs, or peritoneum)
Symptoms are usually more severe and may include worsening pain, profound weakness, shortness of breath, fluid buildup, and cachexia
Care often shifts more heavily toward palliative and comfort-focused care, though chemotherapy may still be used
Sources:
American Cancer Society – Pancreatic cancer staging and symptoms
National Cancer Institute (NCI) – Pancreatic cancer stages and treatment
Mayo Clinic – Pancreatic cancer progression
What are the last stages of pancreatic cancer?
Stage 3 and 4 are considered late stage pancreatic cancer.
Stage 3 (locally advanced)
Cancer has spread to major nearby blood vessels but not to distant organs
Symptoms often include persistent abdominal/back pain, weight loss, fatigue, jaundice, and digestive problems
Treatment may still aim to control the cancer and prolong survival (chemo ± radiation), alongside symptom management
Stage 4 (metastatic)
Cancer has spread to distant organs (most often liver, lungs, or peritoneum)
Symptoms are usually more severe and may include worsening pain, profound weakness, shortness of breath, fluid buildup, and cachexia
Care often shifts more heavily toward palliative and comfort-focused care, though chemotherapy may still be used
Sources:
American Cancer Society – Pancreatic cancer staging and symptoms
National Cancer Institute (NCI) – Pancreatic cancer stages and treatment
Mayo Clinic – Pancreatic cancer progression
What are the last stages of pancreatic cancer?
Stage 3 and 4 are considered late stage pancreatic cancer.
Stage 3 (locally advanced)
Cancer has spread to major nearby blood vessels but not to distant organs
Symptoms often include persistent abdominal/back pain, weight loss, fatigue, jaundice, and digestive problems
Treatment may still aim to control the cancer and prolong survival (chemo ± radiation), alongside symptom management
Stage 4 (metastatic)
Cancer has spread to distant organs (most often liver, lungs, or peritoneum)
Symptoms are usually more severe and may include worsening pain, profound weakness, shortness of breath, fluid buildup, and cachexia
Care often shifts more heavily toward palliative and comfort-focused care, though chemotherapy may still be used
Sources:
American Cancer Society – Pancreatic cancer staging and symptoms
National Cancer Institute (NCI) – Pancreatic cancer stages and treatment
Mayo Clinic – Pancreatic cancer progression
What are the latest pancreatic cancer clinical trials available in the US?
Latest pancreatic cancer clinical trial themes in the US:
KRAS-targeted therapies (including KRAS G12D–focused drugs and combinations), a major shift for a disease long considered “undruggable.”
Immunotherapy combinations pairing checkpoint inhibitors with chemo, radiation, or targeted agents to overcome immune resistance.
Tumor-microenvironment strategies (e.g., stromal modulation, CAF targeting) to improve drug penetration.
Personalized/biomarker-driven trials, matching patients by molecular features (DNA repair defects, MSI-H, KRAS subtype).
Post-surgery (adjuvant) and maintenance trials aimed at preventing recurrence after initial treatment.
Sources:
ClinicalTrials.gov – recruiting and recently posted pancreatic cancer studies (2024–2025)
National Cancer Institute (NCI) – Pancreatic cancer clinical trials overview
American Society of Clinical Oncology (ASCO) meeting updates
What are the latest pancreatic cancer clinical trials available in the US?
Latest pancreatic cancer clinical trial themes in the US:
KRAS-targeted therapies (including KRAS G12D–focused drugs and combinations), a major shift for a disease long considered “undruggable.”
Immunotherapy combinations pairing checkpoint inhibitors with chemo, radiation, or targeted agents to overcome immune resistance.
Tumor-microenvironment strategies (e.g., stromal modulation, CAF targeting) to improve drug penetration.
Personalized/biomarker-driven trials, matching patients by molecular features (DNA repair defects, MSI-H, KRAS subtype).
Post-surgery (adjuvant) and maintenance trials aimed at preventing recurrence after initial treatment.
Sources:
ClinicalTrials.gov – recruiting and recently posted pancreatic cancer studies (2024–2025)
National Cancer Institute (NCI) – Pancreatic cancer clinical trials overview
American Society of Clinical Oncology (ASCO) meeting updates
What are the latest pancreatic cancer clinical trials available in the US?
Latest pancreatic cancer clinical trial themes in the US:
KRAS-targeted therapies (including KRAS G12D–focused drugs and combinations), a major shift for a disease long considered “undruggable.”
Immunotherapy combinations pairing checkpoint inhibitors with chemo, radiation, or targeted agents to overcome immune resistance.
Tumor-microenvironment strategies (e.g., stromal modulation, CAF targeting) to improve drug penetration.
Personalized/biomarker-driven trials, matching patients by molecular features (DNA repair defects, MSI-H, KRAS subtype).
Post-surgery (adjuvant) and maintenance trials aimed at preventing recurrence after initial treatment.
Sources:
ClinicalTrials.gov – recruiting and recently posted pancreatic cancer studies (2024–2025)
National Cancer Institute (NCI) – Pancreatic cancer clinical trials overview
American Society of Clinical Oncology (ASCO) meeting updates
Which companies sponsor pancreatic cancer clinical trials in the US?
Some of the primary companies sponsoring pancreatic cancer clinical trials in the US are:
Amgen – KRAS-targeted therapies
Bristol Myers Squibb – immunotherapy combinations
AstraZeneca – DNA-damage repair and targeted agents
Merck – checkpoint inhibitor–based trials
Roche / Genentech – targeted and biomarker-driven studies
Revolution Medicines – next-generation KRAS inhibitors
Sources:
ClinicalTrials.gov – recruiting and recently posted pancreatic cancer studies (2024–2025)
ASCO Annual Meeting abstracts and sponsor listings
FDA oncology pipeline and trial disclosures
Which companies sponsor pancreatic cancer clinical trials in the US?
Some of the primary companies sponsoring pancreatic cancer clinical trials in the US are:
Amgen – KRAS-targeted therapies
Bristol Myers Squibb – immunotherapy combinations
AstraZeneca – DNA-damage repair and targeted agents
Merck – checkpoint inhibitor–based trials
Roche / Genentech – targeted and biomarker-driven studies
Revolution Medicines – next-generation KRAS inhibitors
Sources:
ClinicalTrials.gov – recruiting and recently posted pancreatic cancer studies (2024–2025)
ASCO Annual Meeting abstracts and sponsor listings
FDA oncology pipeline and trial disclosures
Which companies sponsor pancreatic cancer clinical trials in the US?
Some of the primary companies sponsoring pancreatic cancer clinical trials in the US are:
Amgen – KRAS-targeted therapies
Bristol Myers Squibb – immunotherapy combinations
AstraZeneca – DNA-damage repair and targeted agents
Merck – checkpoint inhibitor–based trials
Roche / Genentech – targeted and biomarker-driven studies
Revolution Medicines – next-generation KRAS inhibitors
Sources:
ClinicalTrials.gov – recruiting and recently posted pancreatic cancer studies (2024–2025)
ASCO Annual Meeting abstracts and sponsor listings
FDA oncology pipeline and trial disclosures
How North Helps
Highly curated trial matches only
Highly curated trial matches only
Most trial finders ask you to do the work of searching and filtering for a match.
Most trial finders ask you to do the work of searching and filtering for a match.
Less jargon, more real talk
Less jargon, more real talk
We translate matches from medical-speak into plain English so that you can understand them.
We translate matches from medical-speak into plain English so that you can understand them.
Human introductions to sites
Human introductions to sites
Instead of cold referrals, we make personal introductions to site coordinators near you.
Instead of cold referrals, we make personal introductions to site coordinators near you.
Why consider a trial?
Access new treatments
Access new treatments
Try promising therapies not yet available outside of the trial.
Try promising therapies not yet available outside of the trial.
Advance cancer research
Advance cancer research
Help move science forward for future patients like you.
Help move science forward for future patients like you.
Understand your options
Understand your options
Explore the possibilities before making treatment decisions.
Explore the possibilities before making treatment decisions.
Questions about North
How is North different from other cancer trial finders?
North makes it easy to find cancer clinical trials that actually fit you. Instead of long lists and medical jargon, our platform takes you through a short and simple health history intake and shows only the trials you’re likely eligible for—near where you live. You can complete matching online or by phone, and if there’s a fit, we connect you directly to the enrolling site. It’s fast, private, and built to help you explore every treatment option available to you.
How is North different from other cancer trial finders?
North makes it easy to find cancer clinical trials that actually fit you. Instead of long lists and medical jargon, our platform takes you through a short and simple health history intake and shows only the trials you’re likely eligible for—near where you live. You can complete matching online or by phone, and if there’s a fit, we connect you directly to the enrolling site. It’s fast, private, and built to help you explore every treatment option available to you.
How is North different from other cancer trial finders?
North makes it easy to find cancer clinical trials that actually fit you. Instead of long lists and medical jargon, our platform takes you through a short and simple health history intake and shows only the trials you’re likely eligible for—near where you live. You can complete matching online or by phone, and if there’s a fit, we connect you directly to the enrolling site. It’s fast, private, and built to help you explore every treatment option available to you.
How much does North cost to use as a patient?
North is free to you, forever. Our trial platform is funded by clinical trial sponsors and sites, so there's no cost to the patient. We're dedicated to matching you with trials that prioritize your needs. Once you've been successfully matched to a trial, the study treatment are provided at no cost to you and you will, in most cases, be reimbursed for study-related expenses.
How much does North cost to use as a patient?
North is free to you, forever. Our trial platform is funded by clinical trial sponsors and sites, so there's no cost to the patient. We're dedicated to matching you with trials that prioritize your needs. Once you've been successfully matched to a trial, the study treatment are provided at no cost to you and you will, in most cases, be reimbursed for study-related expenses.
How much does North cost to use as a patient?
North is free to you, forever. Our trial platform is funded by clinical trial sponsors and sites, so there's no cost to the patient. We're dedicated to matching you with trials that prioritize your needs. Once you've been successfully matched to a trial, the study treatment are provided at no cost to you and you will, in most cases, be reimbursed for study-related expenses.
How often is trial information updated on North?
Trials on North are updated every day to make sure you’re seeing studies that are currently enrolling and reflect the latest eligibility criteria from sponsors and sites. Our daily refresh keeps trial details accurate, so you never waste time on studies that have closed or changed.
How often is trial information updated on North?
Trials on North are updated every day to make sure you’re seeing studies that are currently enrolling and reflect the latest eligibility criteria from sponsors and sites. Our daily refresh keeps trial details accurate, so you never waste time on studies that have closed or changed.
How often is trial information updated on North?
Trials on North are updated every day to make sure you’re seeing studies that are currently enrolling and reflect the latest eligibility criteria from sponsors and sites. Our daily refresh keeps trial details accurate, so you never waste time on studies that have closed or changed.
What types of trials does North have access to?
North has access to over 7,000 cancer clinical trials across leading research networks and hospitals in the U.S. This includes studies for both common and rare cancers, such as lung (small cell and non-small cell), breast (HER2-positive, triple-negative, metastatic), kidney (renal cell carcinoma), colorectal, prostate, and other solid tumors.
These trials cover multiple phases—from early-stage studies testing new therapies to large-scale Phase 3 trials comparing the latest immunotherapies, targeted drugs, and combination treatments to standard care. North also connects patients to precision medicine trials, which match treatments based on a tumor’s genetic makeup, helping more people access cutting-edge options tailored to their specific cancer.
What types of trials does North have access to?
North has access to over 7,000 cancer clinical trials across leading research networks and hospitals in the U.S. This includes studies for both common and rare cancers, such as lung (small cell and non-small cell), breast (HER2-positive, triple-negative, metastatic), kidney (renal cell carcinoma), colorectal, prostate, and other solid tumors.
These trials cover multiple phases—from early-stage studies testing new therapies to large-scale Phase 3 trials comparing the latest immunotherapies, targeted drugs, and combination treatments to standard care. North also connects patients to precision medicine trials, which match treatments based on a tumor’s genetic makeup, helping more people access cutting-edge options tailored to their specific cancer.
What types of trials does North have access to?
North has access to over 7,000 cancer clinical trials across leading research networks and hospitals in the U.S. This includes studies for both common and rare cancers, such as lung (small cell and non-small cell), breast (HER2-positive, triple-negative, metastatic), kidney (renal cell carcinoma), colorectal, prostate, and other solid tumors.
These trials cover multiple phases—from early-stage studies testing new therapies to large-scale Phase 3 trials comparing the latest immunotherapies, targeted drugs, and combination treatments to standard care. North also connects patients to precision medicine trials, which match treatments based on a tumor’s genetic makeup, helping more people access cutting-edge options tailored to their specific cancer.
Will my information be kept secure and private?
Your privacy and confidentiality are our priority. During your intake, we'll ask you about your cancer diagnosis, any treatment plans or previous treatments, and whether you have any specific markers we should know about. Your personal information will be protected in compliance with relevant laws, and in a manner explained in the informed consent document. We'll never share your information with clinical trials without your consent.
Will my information be kept secure and private?
Your privacy and confidentiality are our priority. During your intake, we'll ask you about your cancer diagnosis, any treatment plans or previous treatments, and whether you have any specific markers we should know about. Your personal information will be protected in compliance with relevant laws, and in a manner explained in the informed consent document. We'll never share your information with clinical trials without your consent.
Will my information be kept secure and private?
Your privacy and confidentiality are our priority. During your intake, we'll ask you about your cancer diagnosis, any treatment plans or previous treatments, and whether you have any specific markers we should know about. Your personal information will be protected in compliance with relevant laws, and in a manner explained in the informed consent document. We'll never share your information with clinical trials without your consent.
